| Are relevant procedures well implemented in the UK? | Questions related to how well the condition is currently detected and managed. |
| Does screening reduce morbidity or mortality? | Questions on the impact of screening on preventing more severe health outcomes. |
| Does treatment prevent future problems? | Questions assessing how far treatments begun as a result of screening can improve existing disease and/or prevent the development of more serious problems. |
| How common is the problem? | Questions assessing the number of people affected by the disease or problem. |
| Is the screening test accurate? | Questions on the accuracy of the test or tests at detecting the underlying problem. |
| What long-term problems are likely if untreated? | Questions assessing the normal development of the disease and the more severe problems that are likely to develop if the problem is not addressed after screening. |