Key
| Questions | |
| Incidence | 2. What is the incidence and prevalence of ARDS? |
| Features | 3. What are the features, comorbidities and natural history of ARDS? |
| Diagnosis | 4. How is ARDS diagnosed and classified? |
| Subgroups | 5. Are there clear, relevant subgroups in ARDS? |
| Treatment | 6. What treatment options are there in ARDS? |
| Efficacy | 7. How effective are the treatment options in ARDS? |
| Outcomes | 8. What are the most common outcomes in clinical trials of ARDS? |
| Ongoing | 9. What is the focus of ongoing clinical research in ARDS? |
| PRO tools | 10. What PRO instruments have been used in ARDS? |
| QOL | 11. What is the impact of ARDS on quality of life? |
| Economic | 12. What are the costs associated with ARDS? |
| Unmet needs | 13. What is the unmet need in ARDS? |
Prioritisation strategy for included studies:
- Any relevant primary publications from 2000 onwards
- Any relevant ongoing clinical trial records with a completion date of 2019 onwards
Comorbidities
| CVD | Arrhythmia, heart diseases, chronic heart failure, hypertension, stroke and other cardiovascular diseases |
| Gastrointestinal | GI bleed, gastroesophageal reflux disorder |
| Haematology | Transfusions, thrombotic thrombocytopenic purpura |
| Hepatic | Chronic liver failure, liver dysfunction |
| Lifestyle | Alcohol, drug abuse, malnutrition, obesity, smoking |
| Renal | Chronic kidney failure, chronic renal disease, acute kidney injury |
| Respiratory | Aspiration, asthma, chronic obstructive pulmonary disease, obstructive sleep apnoea, pulmonary contusion |
| Various | DRESS, overdose, pain, pyrexia of unknown origin |